
© Juan Gaertner/SPLA new gene-editing tool called prime editing allows for greater precision and control over DNA edits compared to the popular CRISPR-Cas9 system (pictured).
The system allows researchers more control over DNA changes, potentially opening up conditions that have challenged gene-editors.
For all the ease with which the wildly popular CRISPR-Cas9 gene-editing tool alters genomes, it's still somewhat clunky and prone to errors and unintended effects. Now, a recently developed alternative offers greater control over genome edits — an advance that could be particularly important for developing gene therapies.
The alternative method, called prime editing, improves the chances that researchers will end up with only the edits they want, instead of a mix of changes that they can't predict. The tool, described in a study published on 21 October in
Nature,
also reduces the 'off-target' effects that are a key challenge for some applications of the standard CRISPR-Cas9 system. That could make prime-editing-based gene therapies safer for use in people.
The tool also seems capable of making a wider variety of edits, which might one day allow it to be used to treat the many genetic diseases that have so far stymied gene-editors.
David Liu, a chemical biologist at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts and lead study author, estimates that
prime editing might help researchers tackle nearly 90% of the more than 75,000 disease-associated DNA variants listed in ClinVar, a public database developed by the US National Institutes of Health.
Comment: These Google AI scientists seem to leave out the biggest reason their project is even being funded - and how it is likely to be implemented: for the technocratic subjugation of the domestic populace, and the powering of war against "adversaries" abroad; "and if a few cool quantum batteries can be produced for regular industrial consumption, well, that's fine too."