Six weeks of physical exercise led to changes in the epigenetic information of skeletal muscle cells in young men. These changes took place in areas of the genome that have been linked to disease.
Scientists at the University of Copenhagen say their research shows, for the first time, how exercise remodels DNA in skeletal muscle, so that new signals are established to keep the body healthy.

© University of Copenhagen
While it is widely known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play are not fully known. Now scientists at the University of Copenhagen have discovered that the beneficial effects of physical exercise may in part result from changes to the structure of our DNA. These changes are referred as 'epigenetic'
.DNA is the molecular instruction manual found in all our cells. Some sections of our DNA are genes, which are instructions for building proteins - the body's building blocks - while other sections are called enhancers that regulate which genes are switched on or off, when, and in which tissue. The scientists found, for the first time, that exercise rewires the enhancers in regions of our DNA that are known to be associated with the risk to develop disease.
"Our findings provide a mechanism for the known beneficial effects of exercise. By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect," says
Professor Romain Barrès from the Novo Nordisk Foundation Center for Basic Metabolic Research, the senior author of the research, which was published in
Molecular Metabolism.
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