Greece doesn't support the sanctions against Russia as they are a "road to nowhere," Tsipras said in an exclusive interview for Russia's TASS news agency published on Tuesday.
The visit to Moscow due on April 8 is expected to give a fresh impetus to the Russian-Greek relations, Tsipras said.
"This is a possibility for their true reset," he said.
Tsipras singled out energy, trade, agriculture and tourism as the key areas offering opportunities for boosting bilateral relationship.
He went on to say the Russian ban on imports of agricultural produce from the EU has dealt a heavy blow to Greek farmers, inflicting a serious damage to the Greek economy.
"We are in a geopolitical environment of special tensions and have common challenges, and we need to look at how we treat them," the Greek Prime Minister said.
"The new European security architecture must include Russia," he said.
Comment: At least no zombies were involved this time:
'Zombie Apocalypse' hoax message on U.S. Emergency Alert System broadcast on 10 channels across 5 states
Update 2: Security experts doubt TV stations' "lax passwords" to blame for Zombie Apocalypse EAS hoax: Report sent to DHS last month warned of "multiple undisclosed authentication bypasses"