Using a new survey tool they call RD-SPRITE, Caltech researchers, in cooperation with others at USC and UCLA, mapped the spatial organization of all the DNA and RNA in the nucleus. It was challenging, they admit, to explore the spatial roles of RNA transcripts that don't produce proteins, because the nucleus is a dynamic place crowded with DNA, proteins, and numerous RNAs of unknown function. Let them explain in their paper in Cell1 what they found in the resulting maps:
These maps reveal higher-order RNA-chromatin structures associated with three major classes of nuclear function: RNA processing, heterochromatin assembly, and gene regulation. These data demonstrate that hundreds of ncRNAs form high-concentration territories throughout the nucleus, that specific RNAs are required to recruit various regulators into these territories, and that these RNAs can shape long-range DNA contacts, heterochromatin assembly, and gene expression. These results demonstrate a mechanism where RNAs form high-concentration territories, bind to diffusible regulators, and guide them into compartments to regulate essential nuclear functions. [Emphasis added.]














Comment: That anyone ever seriously considered anything within the biological genome as "junk" or without function is laughable in hindsight. Nothing within the highly organized microbiology of life is useless owing to the transcendent intelligence of its designers. As stated above, the materialist bias truly blinds one from perception of Truth.
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