
© Suzanne Tucker | ShutterstockSocial isolation during critical years of maturation can wreak havoc on the brain, scientists report in the Sept. 13, 2012, issue of the journal Science.
Social isolation in youth may wreak havoc on the brain by disrupting a protein crucial to the development of the nervous system's support cells, new research finds.
A new study in mice finds that when the animals are isolated during a crucial early period, brain cells called oligodendrocytes fail to mature properly. Oligodendrocytes build the fatty, insulating sheathes that cushion neurons, and their dysfunction seems to cause long-lasting behavioral changes.
Research in rhesus monkeys and humans has shown that
social isolation during childhood has an array of nasty and lifelong effects, from cognitive and social problems in neglected children to working memory troubles in isolated monkeys. These children and monkeys also show abnormalities in the white matter of the
brain, which includes support cells such as oligodendrocytes as well as the fat-covered neural projections that act as the brain's communication system.
But while previous studies had noted a correlation between white matter problems and
cognitive struggles after isolation, they could not prove one caused the other. Gabriel Corfas, a professor of neurology and otolaryngology at Boston Children's Hospital and Harvard Medical School, and his colleagues wanted to understand how the relationship works.
They took baby mice from their
mothers at 21 days of age, right after weaning. Some of the young mice were put in typical laboratory conditions, living in a cage with three other mice. Another group was given an enriched environment, with lots of mousey company and an ever-changing array of toys. The final group of mice was put in individual isolation for two weeks, never seeing another rodent.