
© V. Labrie/Van Andel Research InstituteCLUMPS FOUND HERE - Globs of alpha-synuclein protein (red) found in appendix tissue from healthy individuals add to evidence that the gut plays a role in the development of Parkinson’s disease.
The appendix, a once-dismissed organ now known to play a role in the immune system, may contribute to a person's chances of developing Parkinson's disease.An analysis of data from nearly 1.7 million Swedes found that those who'd had their appendix removed had a lower overall risk of Parkinson's disease. Also, samples of appendix tissue from healthy individuals
revealed protein clumps similar to those found in the brains of Parkinson's patients, researchers report online October 31 in
Science Translational Medicine.
Together, the findings suggest that the appendix may play a role in the early events of Parkinson's disease, Viviane Labrie, a neuroscientist at the Van Andel Research Institute in Grand Rapids, Mich., said at a news conference on October 30.
Parkinson's, which affects more than 10 million people worldwide, is a neurodegenerative disease that leads to difficulty with movement, coordination and balance. It's unknown what causes Parkinson's, but one hallmark of the disease is the death of nerve cells, or neurons, in a brain region called the substantia nigra that helps control movement. Lewy bodies, which are mostly made of
clumped bits of the protein alpha-synuclein (
SN: 1/12/2013, p. 13), also build up in those neurons but the connection between the cells' death and the Lewy bodies isn't clear yet.
Comment: Russia doesn't need to play 'second fiddle' to the US in space exploration as others are willing to collaborate for mutual benefits: