The Human Genome Project, which began in the 1990s, was
Homo sapiens' successful attempt to map out the entirety of our species' DNA. It produced the human reference genome, a finely polished collection of human DNA that's crucial for genetics research and genetics testing services around the world. Integral as it has been to the science community, two researchers at Johns Hopkins University have discovered that the reference genome is missing a piece or two - well, 296,485,284 base pairs of DNA, to be exact.
The reference genome is an essential map of human genetic material that is used as a basis for comparison. When we sequence our own DNA for insight into health, family history, and future disease risk, we chop up the sequence into lots of little pieces and compare stretches of it to the reference genome, looking for areas where we differ. The fundamental problem with this, the scientists write in a recent
paper in
Nature Genetics, is that the
reference genome is based largely on a single person. Considering the myriad genetic differences among the 7.7 billion people alive today, that's obviously not ideal.
Professor of computer science and biostatistics
Steven Salzberg, Ph.D., and
Rachel Sherman, a Ph.D. candidate, make the case that this single reference genome doesn't capture the diversity of human genetics.
Some populations, they add, differ too much from this reference genome. To make their case, they refer to the genomes of 910 individuals from twenty different countries, all of pan-African descent.
Comment: Plasma is also the driving force behind the structure of the universe, according to the electric universe theory. Although the scientists are starting from the unproven assumption that there was a big bang, perhaps this research will reveal more clues to the electrical nature of the universe. See also: Review: "Earth Changes and the Human-Cosmic Connection"