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Examination of thousands of genes from nearly 150 human brains shows the circadian rhythm of gene activity changes with aging, according to a first-of-its-kind study conducted by researchers at the University of Pittsburgh School of Medicine. The findings, published online in the
Proceedings of the National Academy of Sciences, suggest also that
a novel biological clock begins ticking only in the older brain.
A 24-hour circadian rhythm controls nearly all brain and body processes, such as the sleep/wake cycle, metabolism, alertness and cognition, said senior investigator Colleen McClung, Ph.D., associate professor of psychiatry, Pitt School of Medicine. These daily activity patterns are regulated by certain genes that are found in almost all cells, but have rarely been studied in the human brain.
"Studies have reported that older adults tend to perform complex cognitive tasks better in the morning and get worse through the day," Dr. McClung said. "We know also that the circadian rhythm changes with aging, leading to awakening earlier in the morning, fewer hours of sleep and less robust body temperature rhythms."
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