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An international research team led by the University of California, Irvine has identified a system of communication networks that exists among organs and tissues that regulate metabolism. Findings from their study provide, for the first time, a detailed "atlas" illustrating how the body creates and uses energy, and how imbalances in the networks may impact overall health.

Published Sept. 6 in the journal Cell, the research reveals the highly coordinated, multi-tissue metabolism underlying the body's circadian rhythms and examines how disruptions in these rhythms-such as those caused by high-fat diets-induce misalignment among the network clocks and can trigger inflammation, which has been linked to major diseases and can affect lifespan.

Comment: What 'high fat' diets are they referring to? As scientists you would hope they would be more specific, because consumption of animal fat enabled our evolution, but it's evident the majority of vegetable fats that predominate the standard western diet, and which we've been consuming for little more than a century, are lethal.

See: Everything About Fat

Lead author Paolo Sassone-Corsi, Donald Bren Professor of Biological Chemistry at UCI's School of Medicine, first showed the circadian rhythm-metabolism link some 10 years ago, identifying the metabolic pathways through which circadian proteins sense energy levels in cells.

"The human body is a complex, beautifully integrated system that functions at optimum efficiency when the networks are in balance," said Sassone-Corsi, director of UCI's Center for Epigenetics and Metabolism. "When this system is disrupted through misalignment among organs, the body will function at a less-than-optimum level, which may lead to disease. We are presenting a map that illustrates how to achieve the best health possible through proper balance and homeostasis."

The researchers examined a variety of genetic clocks-ranging from those in blood serum, the liver and muscle to those in the brain's prefrontal cortex and hypothalamus, as well as in brown and white body fat. The resultant atlas maps the connections among various organs and tissues, which together make up the so-called body clock that governs day-night patterns of metabolic activity. The team then tested the connections to see how a high-fat diet in mice scrambled the body's fine-tuned metabolic patterns and rewired the communication and coordination among clocks.

Comment: Mice aren't humans so the diet comparison is beyond ridiculous. But what is interesting is that the wrong diet will scramble and even rewire the body's natural rhythms.

"The effects of the high-fat diet give evidence that external factors can disrupt the coordinated metabolic pattern," Sassone-Corsi said, adding that with this atlas, information from one organ or tissue group can provide a systemwide understanding of metabolic irregularities and the illnesses related to them.

Comment: Which could be anything from pollution to WIFI to GMO's to pesticides to cosmic rays. It also tells us that if we find the right inputs for our system we can function at our optimum - something many of us, particular in the Western world, have probably never experienced.

"We can now create an approach to personalized medicine based on an individual's circadian metabolism," he said. "Metabolic profiling is a big-data method of optimizing metabolic health."

The international team partnered with the biomedical company Metabolon on this current research, and they will collaborate on a human study and further exploration of circadian-controlled metabolic networks in other organs and tissue groups.
Explore further: Lung tumors hijack metabolic processes in the liver, study finds

More information: Cell (2018). DOI: 10.1016/j.cell.2018.08.042 ,

Journal reference: Cell

Provided by: University of California, Irvine