
© David Marchal/Science SourceHuman hepegivirus 1 has parts of both hepatitis C virus (above) and human pegivirus.
Don't panic. That's the emphatic message coming from researchers who have
discovered a new virus in human blood. Though it's unclear how common the pathogen is, there's no evidence that it has caused anyone harm, and half of those infected appear to have cleared it.
The newfound virus's genetic sequence shows that it has similarities to hepatitis C, which can cause serious liver damage, and to the harmless—and even helpful—human pegivirus (formerly dubbed hepatitis G). Amit Kapoor, a virologist at Columbia University led the team that identified the new virus—and which has named it human hepegivirus 1, or HHpgV-1—notes that many people understand that humans coexist with myriad bacteria that are not dangerous, but they don't realize the same holds true for some viruses.
The team made the discovery thanks to new, sophisticated techniques for sequencing fragments of RNA and DNA. As part of a search for novel human viruses, the group scoured blood samples from a cohort of 46 people that were collected before and after they received a blood transfusion between 1974 and 1980. Today, stricter policies determine who can donate blood and the blood itself is screened more rigorously. "I thought if I want to know whatever is circulating and unknown these are the best samples," Kapoor says.
Using what's known as "deep sequencing" techniques, Kapoor's team fished for nucleic acid sequences (the building blocks of DNA) of known viruses, and found two people who posttransfusion had what looked like a novel flavivirus, the family that includes hepatitis C and human pegivirus. Based on later blood samples that were analyzed,
both of these people subsequently cleared the virus, the team reports online today in
mBio. Kapoor and his colleagues then looked at 70 more people from that cohort but did not find the HHpgV-1 sequence again.
An analysis of a different batch of stored blood samples, from 106 people who had received many blood products because they had hemophilia, found two more people who harbored HHpgV-1 sequences. These people had persistent infections, one of which lasted at least 5.4 years, but no evidence of a related disease.
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