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The mechanism of DNA binding of the well-studied protein Polycomb, which is vital for cell division and embryogenesis, has finally been deciphered. A remarkable discovery, as it proves that the shape of DNA is at least as important for where the protein binds in the DNA as the DNA sequence. The role of the shape of DNA had not been demonstrated so clearly. Researchers at Radboud University will publish their findings on May 28th in the scientific journal Nature Genetics. [Emphasis added.]A 13-second animation shows how this works. The docking protein MTF2, which ferries Polycomb, needs the DNA to un-twist in order to bind to the site, where Polycomb will switch off specific genes. "MTF2 only recognises the binding spot on the DNA if the helix is in a relatively unwound state," the caption says.
Comment: Additional information about the concerns of CRISPR tech: