
© shutterstockTime to get up.
Have you ever wondered why you don't feel tired until late at night but your spouse is fast asleep at 10 p.m. and wakes spontaneously at 6 a.m.?
We each have an internal biological clock, called a circadian clock, that organizes the internal and external activities of our body around the 24-hour day.
While these clocks can be influenced by exposure to sunlight and electric light, for instance, our genes also play a role in how they function. That's part of the reason that sleep and wake habits can vary from individual to individual. And that may also explain why certain chronotherapies, which help change the timing of the circadian clock, such as light boxes and taking the natural hormone melatonin as a supplement, vary in dose and effectiveness from person to person.
Circadian clocks are found in individual cells of our body. My
research team at the University of Notre Dame is teasing apart the molecular mechanisms of these cellular clocks, looking at how genes and the proteins they produce control the multitude of 24-hour rhythms in our bodily functions.
We think that an improved understanding of the circadian system, from genes through to physiology and behavior, will allow for the development of new and improved chronotherapies.
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