
© ENCODE projectZooming in. This diagram illustrates a chromosome in ever-greater detail, as the ENCODE project drilled down to DNA to study the functional elements of the genome.
The human genome - the sum total of hereditary information in a person - contains a lot more than the protein-coding genes teenagers learn about in school, a massive international project has found. When researchers decided to sequence the human genome in the late 1990s, they were focused on finding those traditional genes so as to identify all the proteins necessary for life. Each gene was thought to be a discrete piece of DNA; the order of its DNA bases - the well-known "letter" molecules that are the building blocks of DNA - were thought to code for a particular protein. But scientists deciphering the human genome found, to their surprise, that these protein-coding genes took up less than 3% of the genome. In between were billions of other bases that seemed to have no purpose.
Now a U.S.-funded project, called the Encyclopedia of DNA Elements (ENCODE), has found that many of these bases do, nevertheless, play a role in human biology: They help determine when a gene is turned on or off, for example. This regulation is what makes one cell a kidney cell, for instance, and another a brain cell. "There's a lot more to the genome than genes," says Mark Gerstein, a bioinformatician at Yale University.
The insights from this project are helping researchers understand the links between genetics and disease. "We are informing disease studies in a way that would be very hard to do otherwise," says Ewan Birney, a bioinformatician at the European Bioinformatics Institute in Hinxton, U.K., who led the ENCODE analysis.
As part of ENCODE, 32 institutions did computer analyses, biochemical tests, and sequencing studies on 147 cell types - six fairly extensively - to find out what each of the genome's 3 billion bases does.
About 80% of the genome is biochemically active, ENCODE's 442 researchers report today in
Nature. Some of these DNA bases serve as landing spots for proteins that influence gene activity. Others are converted into strands of RNA that perform functions themselves, such as gene regulation. (RNA is typically thought of as the intermediary messenger molecule that helps make proteins, but ENCODE showed that much of RNA is an end product and is not used to make proteins.) And many bases are simply places where chemical modifications serve to silence stretches of our chromosomes.
Comment: Indeed, mass eruptions of volcanoes go hand in hand with mass influx of cometary debris. This idea that one single asteroid killed off the dinosaurs is as improbable as it is unscientific. The fact of the matter is that comet swarms periodically load Earth's atmosphere with millions of tonnes of debris, most of which is 'meteor smoke'. This has far greater and more frequent effects than occasional impacts like the one in the Yucatán Peninsula.