
© khuruzero | Shutterstock
Scientists have successfully transformed guinea-pig heart-muscle cells into pacemaker cells, paving the way for a biological alternative to artificial pacemakers.
Pacemaker cells generate electrical activity that guides
heart muscle into beating in an orderly, rhythmic manner. Of the heart's 10 billion cells, fewer than 10,000 are pacemaker cells, which are all clustered in the sinoatrial node of the heart's right upper chamber.
If pacemaker cells go awry due to disease or age, the heart pumps irregularly, at best. Patients whose pacemaker cells have failed, but who still remain healthy enough to undergo surgery often rely on
electronic pacemakers to survive. However, such methods face problems because "electronic devices are limited to their finite battery life," said researcher Hee-Cheol Cho, a cell biologist at Cedars-Sinai Heart Institute in Los Angeles.
Other complications may occur with the devices, including accidental movement away from where the pacemaker was implanted, breakage and entanglement of the electrical wires that are screwed into the heart muscle. Such problems "are not uncommon and could be catastrophic," Cho told TechNewsDaily.
In addition, the devices generally cannot adjust when patients need to change their heart rates to walk faster or run. Moreover, cases of bacterial infection in these devices are rising. "All these problems could be solved by a biological pacemaker that is microscopic in scale and free from all hardware," Cho said.