
© ampyang/ShutterstockScientists have discovered specific nerves responsible for sensing itch. The new discovery could lead to better anti-itch treatments
A mysterious source of itchiness has been found. Certain nerve cells are specialized to detect itchy sensations, and those receptors don't detect painful sensations, according to a new study.
The finding, published Dec. 23 in the journal
Nature Neuroscience, helps resolve a long-standing debate over whether itchiness is just a weird form of pain. Additionally, now that they have pinpointed the responsible nerve fibers, researchers could silence those nerves to develop better anti-itch treatments, said Ethan Lerner, a neuroscientist at Harvard University who was not involved in the study.
"This is a very convincing piece of work," Lerner told LiveScience. Scientists "can perhaps target this particular type of nerve as a means of treating itch, but still allow you to experience the protective aspect of pain."
Itchy mysteryFor decades,
why we itch has been a mystery. While some pain nerves have been found to fire in response to itchy stimulants, nerves that responded solely to itch proved elusive. Some researchers even wondered whether itch and pain were always processed by the same nerve fibers, but interpreted by the brain differently, said study co-author Xinzhong Dong, a neuroscientist at Johns Hopkins University.
But the the urge to scratch seemed different in key ways from the experience of pain. For instance, when a mosquito bites, most people feel a powerful desire to scratch the bite, while the pain of touching a hot stove causes people to recoil, Dong told LiveScience.