Did you ever go to a high school reunion and reflect afterward, "How did I end up on a path so drastically different from the one my old pal took? We grew up in the same neighborhood, went to the same school, played the same sports, joined the same clubs -- what happened?" You might wonder the same thing about cells.
How do two neighboring stem cells in the blastocyst end up becoming completely different mature cell types? This has been a question of ongoing interest for researchers who study embryonic development. These cells theoretically have the same genetic code, and are indistinguishable at the blastocyst state, so what caused them to pursue such dramatically divergent careers in life?
Researchers from UC San Diego and Sandford Burnham Medical Research Institute published an article in
Genes and Development that sheds light on the enigma of cell destiny. Colas
et al. sifted through hundreds of sequences of non-coding microRNA to determine whether it regulates stem cell destiny. They thought to do this because among the many other functions of this non-protein coding region of the genome, microRNA seems to play a key role in regulating various cellular processes. They found two factors that regulate mesoderm, ectoderm, and endoderm formation, which is the initial step in embryonic development after implantation.
By way of a little biology review, we are talking about mammal embryos. Not all organisms develop an ectoderm, mesoderm, and endoderm. Some develop two of these, others do not. Colas
et al. looked at mouse embryos as their model organism, although they did compare them to frog and zebra fish counterparts. Once the cells have been assigned to either the ectoderm, mesoderm, or endoderm layer, they will only become certain cell types. The endoderm tends to form the major organs involved in the digestive system, about half of the major components of the urinary system, as well as the lungs and trachea. The mesoderm tends to form the skeletal structure, skin and connective tissue, the other half of the urinary system, and the circulatory system. The ectoderm forms the nervous system and other parts such as tooth enamel, the lining of the mouth and nostrils, and hair and nails.