
© Prevent Disease
The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food is leading to a new understanding on metabolic disorders, including diabetes.
Scientists at the Salk Institute for Biological Studies, led by Ronald M. Evans, a professor in Salk's Gene Expression Laboratory, showed that two cellular switches found on the nucleus of mouse cells, known as REV-ERB alpha and REV-ERB beta, are essential for maintaining normal sleeping and eating cycles and for metabolism of nutrients from food.
The findings, reported March 29 in
Nature, describe a powerful link between
circadian rhythms and metabolism and suggest a new avenue for understanding disorders of both systems, including jet lag, sleep disorders, obesity and diabetes.
"This fundamentally changes our knowledge about the workings of the circadian clock and how it orchestrates our sleep-wake cycles, when we eat and even the times our bodies metabolize nutrients," says Evans.
Nurses, emergency personnel and others who work shifts that alter the normal 24-hour cycle of waking and sleeping are at much higher risk for a number of diseases, including metabolic disorders such as diabetes. To address this, scientists are trying to understand precisely how the biological clock works and uncover possible underlying mechanisms that could adjust the circadian rhythm in people with sleep disorders and circadian-associated metabolic disorders.
In mammals, the circadian timing system is orchestrated by a central clock in the brain and subsidiary clocks in most other organs. The master clock in the brain is set by light and determines the overall diurnal or nocturnal preference of an animal, including sleep-wake cycles and feeding behavior.