
© Thomas Deerinck, National Center for Microscopy and Imaging Research, UC San Diego.A photomicrograph of superficial keratinocytes or skin cells.
Researchers describe inflammatory mechanism for first time.The biological mechanism of sunburn - the reddish, painful, protective immune response from ultraviolet (UV) radiation - is a consequence of RNA damage to skin cells, report researchers at the University of California, San Diego School of Medicine and elsewhere in the July 8, 2012 Advance Online Publication of
Nature Medicine.
The findings open the way to perhaps eventually blocking the inflammatory process, the scientists said, and have implications for a range of medical conditions and treatments.
"For example, diseases like psoriasis are treated by UV light, but a big side effect is that this treatment increases the risk of skin cancer," said principal investigator Richard L. Gallo, MD, PhD, professor of medicine at UC San Diego School of Medicine and Veterans Affairs San Diego Healthcare System. "Our discovery suggests a way to get the beneficial effects of UV therapy without actually exposing our patients to the harmful UV light. Also, some people have excess sensitivity to UV light, patients with lupus, for example. We are exploring if we can help them by blocking the pathway we discovered."
Using both human skin cells and a mouse model, Gallo, first author Jamie J. Bernard, a post-doctoral researcher, and colleagues found that UVB radiation fractures and tangles elements of non-coding micro-RNA - a special type of RNA inside the cell that does not directly make proteins. Irradiated cells release this altered RNA, provoking healthy, neighboring cells to start a process that results in an inflammatory response intended to remove sun-damaged cells.
Comment: To learn more about antibiotic resistant 'Superbugs' read the following articles:
Superbugs: Will Millions Die Needlessly Before We Act?
New Superbugs Resist Most Powerful Antibiotics
Antibiotic Resistance Marching Across Europe
Common Infections Will Be 'Untreatable' If Antibiotic Misuse Continues
The articles listed below provide additional data regarding the growing concern of the overuse of antibiotics in factory farmed meat production:
U.S. Consumers Say 'No' to Antibiotics for Meat Production
What the USDA Doesn't Want You to Know About Antibiotics and Factory Farms
The FDA Finally Reveals How Many Antibiotics Factory Farms Use
Drugs, Poisons and Metals in Our Meat - USDA Needs A Major Overhaul