
© Gary Moore photoThe “wolf boy” brothers have Ambras syndrome, a single-gene condition that may have inspired the werewolf legend.
Growing up in the 1960s, I collected monster cards: The 60-foot-man and the 50-foot woman, duplicate bodies gestating in giant seed pods, unseen Martians that sucked children into sand pits and returned them devoid of emotion, with telltale marks on the back of the neck. One card featured a very young Michael Landon in
I Was a Teenage Werewolf.Forgive my lapse in political correctness, but I recalled those cards when I saw the word "hypertrichosis" in a recent paper in
PLOS Genetics, because, unfortunately, the condition is also known historically as "werewolf syndrome."
In the paper, geneticist Angela Christiano, PhD, and colleagues at Columbia University analyzed the genomes of a father and son with Ambras syndrome, a form of hypertrichosis - and found something intriguing about the causative mutation that has repercussions for genetic testing in general.
A WEREWOLF PRIMERBefore a genetic explanation for overactive hair follicles existed, werewolfism, aka lycanthropy, was thought to arise in eclectic ways: rubbing a magic salve into the skin, sleeping outdoors under a summer full moon, drinking from the pawprint of a wolf, or a devil's curse. Werewolves were once considered to be giant extinct lemurs from Madagascar.
Armenian folklore describes a werewolf as a female criminal being punished by coming out at night and eating her children, and then her relatives' children, in order of relatedness.
In 1963 a physician in London, where Warren Zevon tells us werewolves are prevalent, ascribed lycanthropy to the very rare blood disease congenital erythropoietic porphyria. With its attendant hairiness, reddish teeth, pink urine, and aversion to bright light, porphyria would later explain vampires too, although that idea has been
discredited.
Some physicians suggested that hypertrichosis causes lycanthropy, but others argued that the genetic condition was too rare to account for the many werewolves loose on the streets of Europe.