Findings Establish Critical Link Between Structural and Functional Brain Changes During Learning

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Fifteen years ago, a study showed that the brains of London cab drivers had an enlargement in the hippocampus, a brain area associated with navigation. But questions remained: Did the experience of navigating London's complex system of streets change their brains, or did only the people with larger hippocampi succeed in becoming cab drivers?
Now, Carnegie Mellon University scientists have determined that learning detailed navigation information causes the hippocampal brain changes. Published in
NeuroImage, Tim Keller and Marcel Just show for the first time that brief navigation training changes a person's brain tissue and improves how that changed tissue communicates with other brain areas involved with navigation.
The findings establish a critical link between structural and functional brain alterations that happen during spatial learning. They also illustrate that the changes are related to how neural activity synchronizes - or communicates - between the hippocampus and other regions that are important for navigation understanding and learning."The hippocampus has long been known to be involved in spatial learning, but only recently has it been possible to measure changes in human brain tissues as synapses become modified during learning," said Keller, a senior research scientist in CMU's Department of Psychology and Center for Cognitive Brain Imaging (CCBI). "Our findings provide a better understanding of what causes the hippocampal changes and how they are related to communication across a network of areas involved in learning and representing cognitive maps of the world around us."
To examine how the hippocampus changes, Keller and Just recruited 28 young adults with little experience playing action video games. For 45 minutes, the participants played a driving simulation game. One group practiced maneuvering along the same route 20 times. The control group drove for the same amount of time, but along 20 different routes. Before and after each training session, each participant's brain was scanned using diffusion-weighted imaging (DWI),which measures water molecule movement in the brain,and functional magnetic resonance imaging (fMRI), which analyzes brain activity.
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