
© Cell.comPhysics simulation of 5 megabases of DNA forming loops and domains.
Quebec - The new theory for germline guidelines is based on IVF screening practices, and it's pretty damn confronting.
Forget Frankenstein; this is a whole new order of difficulty with a lot of new dangers.In a society where accountability is virtually non-existent, it's also a very high-risk issue.
The ability to edit genes and deal with genetic disorders with genetic screening is either a horror story in progress or a major achievement depending on your point of view. Just about everybody has pointed out that an arbitrary determination of genetic makeup is untrustworthy by definition.
Big money will be in play, and that money usually wants to make a lot more of itself. Greed reproduces itself, too.Given the environment of truly irrational pricing and other depraved evil spirits/scumbags in medical industries, why should these guys be allowed to participate, and make more money, editing the human race?Not to detract from this whole new horizon of fascinating science in any way — the basic process of editing genes in IVF is supposed to manage some truly hideous, crippling, genetic conditions. Fair enough, you'd think. It's a practical way of managing a lot of otherwise catastrophic medical conditions.
Inheritable germline genetic modifications, however,
raise big issues and potentially big problems. Germline is defined by Google as "a series of germ cells each descended or developed from earlier cells in the series, regarded as continuing through successive generations of an organism." Add to this new tech related to genetic modifications, which has literally exploded in the last decade or so since the Human Genome Project, and the whole issue of gene editing gets very tricky, very quickly.
That means that germline edits are permanent and will be carried on in new generations. In human terms, that could mean "selecting or de-selecting" things like human traits, according to researchers at the Centre of Genomics and Policy at McGill University in Quebec.
Umm.... Turning human behaviors on and off? Sounds like a reliable way of causing multiple disasters, doesn't it? Some human behaviors may deserve to be turned off, but who do you trust with this ability? Big Pharma? Big Medicine? Big Politics? The usual insufferable pig-ignorant/do nothing/hate everybody "elites" of every generation? Would you trust a society which wouldn't do well in comparison with a dunghill for rational behavior of its own?Imagine
inheritable behaviors and other characteristics based on the whims of some claque of ideologically and/or money-driven people whose technical knowledge will be superseded in hours or days and whose view of humanity is as rational as a politician's understanding of ethics and accountability.
The inevitable result would be the "genetic fashions" of the day vs real human needs and rights. This would be the culture of gene editing if it doesn't have guidelines and those guidelines can't be enforced. The need for guidelines isn't in question. The question is whether those guidelines can work at all. There are real dangers in this scenario.
Comment: Another small but important sign of how the pace of technology seems to outstrip the foresight and resources required to employ technology wisely.