Four people have reportedly been shot dead at Fort Hood in Texas
According to US media reports, the shooter who has been identified as 34-year-old soldier Ivan Lopez, died of a self-inflicted gunshot wound.
In 2009, the base was the scene of a mass shooting which left 13 people dead and over 30 others injured.
According to White House spokesman Josh Earnest, US President Barack Obama has been informed of the recent shooting incident and will continue to receive updates.
"Any shooting is troubling. Obviously this reopened the pain of what happened at Fort Hood five years ago," said Obama.
"We're heartbroken that something like this might have happened again. I don't want to comment on the facts until we know exactly what happened," he added.
Fort Hood officials say a "shelter in place" order will be lifted as soon as they believe the base is safe.
The shooting comes a few days after two people were shot and killed aboard a guided-missile destroyer at a US Navy base in Norfolk, Virginia.
In another shooting incident last September at the Washington Navy Yard, which is some 200 miles north of Norfolk, a gunman killed 12 people before he was shot dead by police.
Are these soldiers programmed to go off, and if so, why on there own people?