The fire was reported around 2 a.m. Thursday at a home on Motes Lane, off Highway 62 in Greenville, about 35 miles northeast of Hopkinville.
There were 11 people inside the home when the fire broke out.
An adult and a child were able to escape and were being treated for burns and smoke inhalation. Both victims were transported by LifeFlight medical helicopter to Vanderbilt University Medical Center's trauma center in Nashville.
The house was a total loss.
Chief Darren Harvey with the Greenville Fire Department said multiple fire crews on the scene. Police were also on the scene.
Details about the cause of the fire were not available.
NewsChannel 5 has multiple crews on the scene. Stay with NewsChannel 5 for more information as it becomes available.
No official cause released yet but they are suspecting electrical or portable heater...it's been much colder here lately and that has caused more fires than normal. My spouse is a firefighter. They have been keeping more on shift for that reason. The "booms" that were mentioned have not been heard in this part of western ky and if we are under a wildfire warning no one has heard about it in our area. There has been some form of moisture around here every week.