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© Agence France-PresseFiremen try to extinguish a blaze near the eastern Spanish village of Ures de Medina, close to Medinaceli on July 23, 2009.
Horta De Sant Joan -- Some 500 people were battling Wednesday a wind-fuelled wildfire in northeastern Spain which claimed the lives of four firefighters and seriously injured two others, Defence Minister Carme Chacon said Wednesday.

"We are working against the clock with all the human and material means which are capable of working in an area of difficult access," she told public radio RNE from the site of the blaze in Els Port national park near Tarragona.

The four veteran firefighters were killed Tuesday when the direction of the wind suddenly changed, whipping up the blaze and surrounding the men by flames.

It was the worst tragedy in Spain involving firefighters battling a wildfire since 11 were killed in 2005 as they fought a blaze that destroyed about 13,000 hectares (32,000 acres) of pine forest near the central city of Guadalajara.

One of the two firemen is in "very serious condition" in hospital with kidney failure, the head of the health service in Catalonia, Marina Geli, told reporters. The 31-year-old suffered burns to 50 percent of his body.

The other injured fireman, aged 36, suffered burns to 75 percent of his body. His condition was evolving "favourably" she added.

Local officials said the fire, which erupted on Monday amid scorching temperatures, was still not under control.

It has so far ravaged over 800 hectares (1975 acres) of forest and brush and was threatening built-up areas of the municipality of Horta de Sant Joan. Officials evacuated several farmhouses in the area due to risk from the flames.

Temperatures were forecast to reach 41 degrees Celsius (105 degrees Fahrenheit) in many parts of Spain on Wednesday, raising the risk that more wildfires could break out.

Spain lost 155,000 hectares to fire in 2005 and another 188,000 hectares in 2006 but was spared major wildfire damage in the past two years, the exception being the Canary Islands in the Atlantic which suffered major blazes in 2007.