The bugs, known as Harlequin Ladybirds, are flying in from Asia and North America on mild Autumn winds and seeking cosy hibernation spots in people's homes.
The harlequin ladybird, which have black instead of red wings, was introduced to North America in 1988 and arrived in Britain in summer 2004.
The first sightings were in the southeast of England but since then the bug has spread rapidly up to north of England and west into Wales.
Experts say the foreign invaders actually pose a threat to the domestic species because they carry a sexually-transmitted disease called Laboulbeniales fungal disease.
Residents have reported large clusters of the bugs in their living rooms, kitchens and bedrooms this week.
The creepy-crawlies have been seen clustering around boilers, window frames and smoke detectors as they bed down for winter.
Aaron Greenwood shared a photograph of the bugs assembling around a light in his flat - but said he would let them stay.
He told the Manchester Evening News: "I noticed all the articles on social media regarding the ladybird invasion.
"I was with a close friend in my flat having lunch and we both noticed a small insect flying around the room.
"My friend made a comment that it was a fly I could tell it was a ladybird as am a nature fanatic. This laybird flew near my light on my living room roof.
"At closer inspection I could see three more, so I got a straw and envelope and put them in a container and got them outside."
Debbie Phil Tighe wrote: "I've had them today all over my front door and a few inside of my window at the top of the stairs."
Andrea Atkins posted: "My windows are covered in them and had a few in the house."
Peter Wilson shared an image of a ladybird resting on his shoulder after he spotted a number of the creatures travelling on the 50 bus.
Andrea Allen said she saw "hundreds if not thousands" on the trees in Hazel Grove.
Steve McGrail, director of pest control company Pro Kill Environment, said Harlequin Ladybirds are not harmful to humans but recommended sealing windows to make sure they do not get in homes.
He said: "They are a non-indigenious species. They are coming inside in large numbers.
"They usually cluster around window frames and they cluster together to gather heat and hibernate in winter months."
Scientists say a fungus the creatures carry, which is passed on through mating, will infect our native species which are already under threat from habitat loss.
While they do not yet know if the fungus is harmful, the UK Ladybird Survey says it is possible the disease affects the lifespan or the number of eggs a female can produce over her lifespan.
Comment: Invasive ladybirds aren't the only sign that our wildlife is undergoing a drastic shift: