A genetic analysis by latitude reveals variation in a cold-sensing protein linked to migraines
Genetic variation cold sensitive protein
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A certain genetic variation in a cold-sensitive protein is far more common in people of northern European ancestry than in Asians or Africans. This variation has also been linked to migraine headaches, which occur more frequently in this population.

In Finland, 88 percent of people have a genetic variation that increases their risk for migraines. But in people of Nigerian descent, that number drops to 5 percent.

Coincidence? Maybe. But a new study suggests that, thousands of years ago, that particular genetic mutation increased in frequency in northern populations because it somehow made people better suited to handle cold temperatures. That change may have had the unfortunate consequence of raising the prevalence of these severe headaches in certain populations, researchers report May 3 in PLOS Genetics.

The mutation is in a stretch of DNA that controls the behavior of TRPM8, a protein that responds to cold sensation. People with the older version of this DNA snippet seems less susceptible to migraines than people with the mutated version, previous studies have shown.

Using a global database of human genetic information, evolutionary geneticist Aida Andres and her colleagues showed a correlation between the frequency of the mutation in a given population and that population's latitude. It's rare in Africa, for example, but fairly common across Europe.

Differences in temperature may have led to this variation, though scientists still aren't sure exactly how the mutation affects TRPM8. Perhaps the mutation conferred some benefit to early humans who moved north from Africa, says Andres, of University College London. The connection to migraine appears to be a side effect.

The researchers acknowledge, however, that the science of migraines isn't so simple. One variant can't fully explain why these headaches are more common in certain populations. Migraine risk is "very complex," Andres says. "It's highly heritable, but other things impact it, too."

Plus, there's still a lot to learn about TRPM8. "We don't even really know how the entirely normal [protein], with no mutations, contributes to migraine," says Greg Dussor, a neurobiologist at the University of Texas at Dallas who wasn't part of the study.

Even the link between migraine and temperature is muddy: While cold temperatures can trigger migraines in some people, heat sets others off.
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Citations: F. Key et al. Human local adaptation of the TRPM8 cold receptor along a latitudinal cline. PLOS Genetics. May 3, 2018. doi:10.1371/journal.pgen.1007298.