The sheriff's office reported that the infant, who was in the care of family members while his parents were out, was found injured in a bedroom with the dog next to him.
Officials said the infant's parents returned during the call and rushed the baby to the hospital, where he died from his injuries.
Volusia County Animal Services responded to the scene and took possession of the dog, described as a Great Dane and Husky mix weighing 130 pounds.
"Sheriff Chitwood and the entire Sheriff's Office send sincere condolences to the family of the young victim who lost his life in these tragic circumstances," the sheriff's office said in a statement.
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