Sir John Bell, a distinguished scientist and regius professor of medicine at Oxford University, said that the pathogen underpinning the novel virus may never be eliminated.
Giving evidence at a session of the Commons Health and Social Care Committee, Sir John, 68, added that any potential coronavirus vaccine "is unlikely to have a durable effect that'll last for a very long time".
"So we're going to have to have a continual cycle of vaccinations and then more disease, and more vaccinations and more disease." Sir John told the Committee, chaired by former health secretary and Tory MP Jeremy Hunt.
Sir John, knighted for his services to medicine in 2008, used polio as an example of how difficult it can be to completely suppress a disease.
"Look at how much trouble they've had in eliminating, for example, polio, that eradication programme has been going on for 15 years and they're still not there," he said.
"So this [Covid-19] is going to come and go, and we're going to get winters where we get a lot of this virus back in action."
Sir John's comments came less than 24 hours after the government secured early access to 90 million Covid-19 vaccine doses through partnerships with pharmaceutical companies BioNTech and Pfizer.
Researchers at Oxford University also on Monday announced that a vaccine being developed in collaboration with AstraZeneca induces a strong immune response and appears to be safe.
During Tuesday's health committee - in which MPs scrutinised ministers' handling of the pandemic - Sir John said the government had been "asleep" to the threat of the virus.
"The fact that we were asleep to the concept that we were going to have a pandemic, I think, shame on us," he said.
"Since the year 2000 we've had eight close calls of emerging infectious diseases, any one of which could have swept the globe as a pandemic."
He added: "This is not new and I think we should not be proud of the fact that we ended up with a system which had no resilience to pandemics. I think the biggest single failure was not being on the front foot."
Sir Paul Nurse, also giving evidence at the session, said there had been a lack of leadership at the top of government throughout the pandemic.
The Nobel Prize-winning geneticist warned that the UK risks sleepwalking into a "winter of discontent" unless clear governance structures are implemented for the remainder of the pandemic.
"It's not always been clear at least to me and my colleagues as to who is in charge exactly and whose been making decisions," he said.
"My experience in talking to advisers and also politicians is that I've never found it too easy to find out who is responsible for the different parts of the strategy and for that matter the tactics that are being put in place. I have a sense there has been too much pass the parcel."
Comment: Brilliant! Let's make rushed vaccines that become obsolete for a virus that both easily mutates and has an infinitesimally low mortality rate even using inflated statistics. Surely, that will help us through the pandemic that has only ever existed in peoples' deluded nightmare that they mistake as reality.