Scientists can finally explain exactly how and why a cell's defences fail against some invaders, including the plague, while successfully fending off others.
A new super-resolution microscopy technique is providing researchers with never-before-seen detail of a cell membrane.
They claim the development could open doors to new diagnostic, prevention and treatment techniques.
© Jerl Timlin, Jesse Aaron and Bryan CarsonBefore and after: What scientists used to be able to see on a cell's surface (left), compared to what they can now see (right). Orange areas show the bacteria LPS, derived from E. coli, while the green areas show the cell's TLR4 receptors
Jesse Aaron, a researcher at of Sandia National Laboratories, said: 'We're trying to do molecular biology with a microscope, but in order to do that, we must be able to look at things on a molecular scale.'
The cell membrane is a bustling hub of activity on a minuscule scale. While providing structure and housing the cell's interior, the membrane regulates movement of materials in and out of the cell, controls adhesion to other objects and co-ordinates the cell's communications and subsequent actions through signalling.
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