Brain's code for visual working memory deciphered in monkeys -- NIH-funded study.The brain holds in mind what has just been seen by synchronizing brain waves in a working memory circuit, an animal study supported by the National Institutes of Health suggests. The more in-sync such electrical signals of neurons were in two key hubs of the circuit, the more those cells held the short-term memory of a just-seen object.
Charles Gray, Ph.D., of Montana State University, Bozeman, a grantee of NIH's National Institute of Mental Health (NIMH), and colleagues, report their findings Nov. 1, 2012, online, in the journal
Science Express.

© Charles Gray, Ph.D., Montana State UniversityA brain visual working memory circuit holds information in mind about what has just been seen. It represents the memory and distinguishes among objects via unique patterns of brain wave synchronization between neurons in the circuit. The large area of red in the lowest graph indicates that the brain waves in the two regions were highly in-sync after seeing a particular object – indicating that they were highly involved in holding in short-term memory information about that object. The modest amount of red for the top graph indicates lesser involvement for another object. By contrast, lack of red in the middle graph shows that the two groups of neurons weren't much involved in remembering a third object. So the memory of any particular object appears to be represented by its own unique mix of neurons oscillating in-sync.
"This work demonstrates, for the first time, that there is information about short term memories reflected in in-sync brainwaves," explained Gray.
"The Holy Grail of neuroscience has been to understand how and where information is encoded in the brain. This study provides more evidence that large scale electrical oscillations across distant brain regions may carry information for visual memories," said NIMH director Thomas R. Insel, M.D.