© 3DScience.com
Gliomas (tumors in the brain) are especially aggressive malignant forms of cancer, often resulting in the death of affected patients within one to two years following diagnosis. There is no cure for gliomas and most available treatments provide only minor symptomatic relief.
A review of the modern scientific literature reveals numerous preclinical studies and one pilot clinical study demonstrating cannabinoids' ability to act as antineoplastic agents, particularly on glioma cell lines.
Writing in the September 1998 issue of the journal
FEBS Letters, investigators at Madrid's Complutense University, School of Biology, first reported that delta-9-THC induced apoptosis (programmed cell death) in glioma cells in culture.[1] Investigators followed up their initial findings in 2000, reporting that the administration of both THC and the synthetic cannabinoid agonist
WIN 55,212-2 "induced a considerable regression of malignant gliomas" in animals.[2] Researchers again confirmed cannabinoids' ability to inhibit tumor growth in animals in 2003.[3]