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Antibodies were patterned onto flexible plastic films using the flexographic printing process...Printing antibody features such as dots, squares, text, and fine lines were reproduced effectively. Furthermore, this process could be easily adapted for printing of other biological materials, including, but not limited to, enzymes, DNA, proteins, aptamers, and cells.[1]This concept - and now reality - of creating plastic antibodies and associated biological components, to be used for "medicinal purposes" within the human organism, is technically a form of cybernetics; that is, combining artificial technologies and biological systems to create human-machine hybrids (i.e. cyborgs) with enhanced abilities. While the trans-humanistic ethos which subtends cybernetic technology is, for lack of a better word, creepy, the successes of synthetic antibodies have recently been lauded in both the experimental literature and mainstream media, alike.
We report that simple, synthetic organic polymer nanoparticles (NPs) can capture and clear a target peptide toxin in the bloodstream of living mice. The protein-sized polymer nanoparticles, with a binding affinity and selectivity comparable to those of natural antibodies, were prepared by combining a functional monomer optimization strategy with molecular-imprinting nanoparticle synthesis. As a result of binding and removal of melittin by NPs in vivo, the mortality and peripheral toxic symptoms due to melittin were significantly diminished. In vivo imaging of the polymer nanoparticles (or"plastic antibodies") established that the NPs accelerate clearance of the peptide from blood and accumulate in the liver. Coupled with their biocompatibility and nontoxic characteristics, plastic antibodies offer the potential for neutralizing a wide range of biomacromolecules in vivo.[2]The unintended, adverse effects of injecting plastic antibodies into animals or humans in order to improve on, optimize or replace natural immune processes, are likely immense. Plastic, after all, is a derivative of crude oil, and lacks biocompatibility with most living systems (being therefore xenobiotic), excluding rare forms of bacteria and fungi. It is likely that if we continue to see overwhelmingly positive reports such as this in the animal model, it will only be a matter of time until human clinical trials begin, and FDA approval becomes a very real possibility.
From 1990 to the present, the number of cases (n = 31) and deaths (n = 12) from YEL-AVD [attenuated yellow fever vaccine] in travelers has exceeded the reports of YF [wild-type yellow fever] (n = 6) acquired by natural infection, raising the question whether the risk of vaccination exceeds the benefit in travelers.1Say what?
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