
© Ronan McCloskeyThe skeleton of the famous Irish Giant Charles Byrne, who lived from 1761 to 1783, exhibited at the Hunterian Museum in London.
He was a giant of a man, 7 feet 7 inches tall, who left his home in Ireland when he was 19 and traveled to London to make his fortune as a freak. There Charles Byrne, known as the Irish Giant, garnered wealth and fame. But, suffering from tuberculosis and an excessive love of gin, he died a few years later, in 1783. A surgeon - John Hunter - bought Mr. Byrne's corpse, boiled it in acid to remove the flesh, and exhibited the skeleton in his museum in London.
And there the bones remained, studied in 1909 by the renowned American surgeon Harvey Cushing, who removed the top of the skull and pronounced that Mr. Byrne had had a pituitary tumor. Other than that, Mr. Byrne remained a curiosity, a famous giant, the subject of a 1998 novel by the British writer
Hilary Mantel, yet, with only a skeleton remaining, of little interest to science.
Until now: researchers in Britain and Germany have extracted DNA from Mr. Byrne's teeth and solved the mystery of his excessive height.
It turned out to be a rare and mysterious gene mutation, discovered only in 2006. The researchers then found the mutation in four families from Northern Ireland, near where Mr. Byrne was born. Following a hunch, they decided to ask whether Mr. Byrne had had the mutation, too, and whether the mutation indicated that the four families were related to him. Their hunch was right.