Scientists at the Doherty Institute and Monash University say they have discovered immune cells that could fight off all forms of the flu virus, which could see an end to annual flu jabs.
Depending on a patient's immune system, a cover-all flu shot would only be needed every 10 years, or potentially just once in a lifetime - and could help prevent thousands of deaths worldwide every year.
"We have identified the parts of the virus that are shared across all flu strains, and sub-strains capable of infecting humans, and then investigated if we could find robust responses to those viral parts in healthy humans, and influenza-infected adults and children," University of Melbourne PhD student, Marios Koutsakos, said.
Mr Koutsakos was part of a team led by Professor Katherine Kedzierska from Melbourne's Doherty Institute, which had its discovery published the scientific journal, Nature Immunology.
"Influenza viruses continuously mutate to evade recognition by our immune system, and they are vastly diverse, making it nearly impossible to predict and vaccinate against the strain that will cause the next influenza pandemic," Mr Koutsakos said.
The vaccine that can beat the flu in whatever form it comes is considered medicine's holy grail in tackling a deadly global scourge of the winter months, and researchers they have now identified virus parts that have not changed for more than a century, which can be attacked by killer T cells.
"It was really like finding a needle in a haystack. We started with 67,000 viral sequences and narrowed it down to three sequences that the killer T-cells can recognise," Professor Kedzierska said.
But because of DNA quirks, Professor Kedzierska says the breakthrough super vaccine would be effective for only the half of the world's population that has the killer T-cells.
"Now what we are working on is using similar cutting-edge technology is to find similar killer T-cells for the rest of the global population so we can protect everyone," she said.
Depending on a patient's immune system, a cover-all flu shot would only be needed every ten years, or potentially just once in a lifetime.
A universal vaccine has the potential to be a significant lifesaver.
As recently as 2017, a particularly virulent flu strain led to a record number of infections and an estimated four thousand deaths worldwide.
The current Northern Hemisphere flu season has killed a thousand people in France alone. At least fifty-six have also died in Greece and it's feared many more are vulnerable.
Reader Comments
I think the problem is that scientists are all militant optimists. Watch Sagan's Cosmos for example, full of information but somehow this childlike innocence radiates off of him.
That would be something if it was actually the influenza that was doing the killing.
"Meanwhile Doctors Slack and Overlander were busy taking cultures. They soon reported that the influenza bacillus predominated in these cultures. They also found that both Type I and Type III of the pneumococci were present. They also found streptococci. Their reports indicated that the present epidemic was a mixed infection. In getting the history of the cases, Doctor Harrington found that the worst cases
of pneumonia came from that part of the ships where the ventilation was the worst. Doctor Slack's analyses clearly demonstrated that we had to deal with the pusproducing pneumococcus. We were able to get reports from the autopsies at the Naval Hospital, showing that the men died, not from heart failure, but from abscesses in the lungs. This explained why the heart stimulants had had practically no effect on the cyanosed patients, and that they died, not from heart failure, but from lack of air....The infection itself, as has been stated previously, was a mixed infection; and where Type III of the pneumococcus predominated many of the cases were fatal. In many of the cases of pneumonia, the diagnosis was made by Doctors Slack and Overlander from the sputum before any signs could be detected in the chest." The American Journal of Public Health, October, 1918. THE OPEN AIR TREATMENT OF INFLUENZA. WILLIAM A. BROOKS, Surgeon-General, Massachusetts State Guard.
The pneumococci found in the military hospital patients were later traced to "vaccinations" administered to troops in Ft Riley, Kansas. That was the source of the "influenza" epidemic a century ago. Killed more people than troops who died of battle wounds.