Health & WellnessS


Wolf

How the brain generates delusions

brain
People with certain types of brain disorders can suffer from delusions, which are erroneous beliefs in objects or situations that remain fixed in the mind despite evidence they are incorrect. Delusions make it hard for people to function with any normalcy in the real world and confound the doctors and therapists who are trying to help them.

Research published this week in the journal Neurology makes an important observation about the brains of people with neurological disorders, such as those with brain damage from strokes and Alzheimer's disease who suffer delusions, and suggests a novel theory for why delusions occur and persist.

Sherlock

A Link Between Autism and Testosterone?

Autism Ultrasound
© Getty ImagesA British researcher claims his study may lead to early screening for autism via amniocentesis.
A researcher who describes autism as a condition of the "extreme male brain" says fetuses exposed in the womb to high levels of the male hormone testosterone are more likely than others to develop autistic traits as children.

Simon Baron-Cohen, director of Cambridge University's Autism Research Centre, has shown in past research that men are more likely than women to score low on tests of empathy but high on tests of "systemizing" - recognizing rules and patterns - characteristics that, in the extreme, define autism. That's what led Baron-Cohen to regard the disorder - which is about three to four times as prevalent in boys as in girls - as one of the extreme male brain and to search for a link to male hormones.

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Scientists Discover Gene Responsible for Brain's Aging

Will scientists one day be able to slow the aging of the brain and prevent diseases such as Alzheimer's and Parkinson's? Absolutely - once the genetic coding associated with neuronal degeneration has been unraveled.

According to a new study published in The Journal of Neuroscience, a research team from the Université de Montréal, Maisonneuve-Rosemont Hospital and Lawrence Berkeley National Laboratory has taken a giant step in this direction by identifying a gene that controls the normal and pathological aging of neurons in the central nervous system: Bmi1.

The primary risk factor for diseases such as macular degeneration, Parkinson's and Alzheimer's is age. Although many researchers have sought to better understand the genetics and pathophysiology of these diseases, few studies have focused on the basic molecular mechanisms that control neuronal aging.

Family

DVD teach autistic kids what a smile means

baron-cohen autism
© AP Photo/Brian HarrisSeptember 2008 file photo of Professor Simon Baron-Cohen photographed in the Great Court at Trinity College, Cambridge England. For the past three years, Professor Baron-Cohen has been working on a cartoon series that new research shows is dramatically effective in helping children with autism understand and recognise emotions. The DVD 'The Transporters' goes on sale in United States on January 12.
London - It wasn't until Jude met Jenny that the 3-year-old autistic boy understood what happy people look like.

Jenny, a green tram with a human face, had a furrowed brow when her wheel buckled and she got stuck on a track. But after being rescued by friends, she smiled broadly - and that's when something clicked for little Jude Baines.

"It was revelatory," his mother, Caron Freeborn told AP Television News in Cambridge, England. Before watching the video, Jude didn't understand what emotions were and never noticed the expressions on people's faces, even those of his parents or younger brother.

Jenny's adventures are part of a DVD for autistic children released this week in the United States called The Transporters.

The DVD teaches autistic children how to recognize emotions like happiness, anger and sadness through the exploits of vehicles including a train, a ferry, and a cable car.

Alarm Clock

Flashback The Mystery of Borderline Personality Disorder

Borderline
© istock PhotoBorderline Personality Disorder. Photo-illustration for TIME by Andree Kahlmorgan.
Doctors used to have poetic names for diseases. A physician would speak of consumption because the illness seemed to eat you from within. Now we just use the name of the bacterium that causes the illness: tuberculosis. Psychology, though, remains a profession practiced partly as science and partly as linguistic art.

Because our knowledge of the mind's afflictions remains so limited, psychologists - even when writing in academic publications - still deploy metaphors to understand difficult disorders. And possibly the most difficult of all to fathom - and thus one of the most creatively named - is the mysterious-sounding borderline personality disorder (BPD). University of Washington psychologist Marsha Linehan, one of the world's leading experts on BPD, describes it this way: "Borderline individuals are the psychological equivalent of third-degree-burn patients. They simply have, so to speak, no emotional skin. Even the slightest touch or movement can create immense suffering."

People

Why So Many Minds Think Alike

Brain
© National Institutes of HealthImaging techniques help scientists look at the basis for principles of social psychology in the brain.
You're in a room with 10 other people who seem to agree on something, but you hold the opposite view. Do you say something? Or do you just go along with the others?

Decades of research show people tend to go along with the majority view, even if that view is objectively incorrect. Now, scientists are supporting those theories with brain images.

A new study in the journal Neuron shows when people hold an opinion differing from others in a group, their brains produce an error signal. A zone of the brain popularly called the "oops area" becomes extra active, while the "reward area" slows down, making us think we are too different.

Syringe

Researchers Detail How Aging Undermines Bone Healing

Researchers have unraveled crucial details of how aging causes broken bones to heal slowly, or not at all, according to study results published today in the Journal of Bone and Mineral Research. The research team also successfully conducted preclinical tests on a potential new class of treatments designed to "rescue" healing capability lost to aging.

In the worst cases, an age-related delay in healing keeps the two sides of a fractured bone from ever rejoining (non-union), leaving many confined to wheelchairs, unable to walk or to live independently. Of the estimated 5.6 million fractures in the United States each year, between five and ten percent (up to 560,000) will heal slowly or incompletely. Researchers have known for 30 years that aging interferes with fracture healing, and have been filling in the details since on the complex web of biochemicals, stem cells and genes that bring about healing. The field is now reaching the point where precision designed drugs are in different stages of animal and human trials.

The current study is focused on cyclooxygenase 2 (COX-2), an enzyme known from past studies to drive stem cells to differentiate into cartilage, which then matures into bone. Researchers at the University of Rochester Medical Center 20 years ago discovered the gene in humans that is responsible for producing the COX-2 enzyme and revealed the enzyme's role in causing inflammation, the reason drugs like the painkiller Vioxx were developed to shut down its action. Then about seven years ago another research team here determined that COX-2 also plays an essential role in bone formation during skeletal repair.

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DREAM: One Gene Regulates Pain, Learning And Memory

The DREAM-gene which is crucial in regulating pain perception seems to also influence learning and memory. This is the result of studies carried out by researchers in Seville, Spain, and Vienna, Austria. The new findings could help explain the mechanisms of Alzheimer's disease and yield a potential new therapeutic target.

In 2002, a group of scientists at the University of Toronto was able to identify a gene which they dubbed DREAM (downstream regulatory element antagonistic modulator). The gene's function was highly interesting: it obviously served as a key regulator in the perception of pain. Mice who lacked the gene showed clear signs of markedly reduced sensitivity to all kinds of pain, whether chronic or acute. Otherwise, the mice appeared perfectly normal.

The work leading to these findings was carried out in the lab of Josef Penninger, then principal investigator at the Amgen Institute in Toronto. The publication describing the gene's function was received with great interest (Cell, Vol. 108, 31-43, 11.1.2002) and DREAM was subsequently termed the "Master-Gene of pain perception".

Health

Is it really bad to be sad?

Image
© UnknownMedicating Misery

Why be miserable? OK, so it's January and you're feeling fat and broke after the excesses of the holiday season, but there's really no need. Misery is inconvenient, unpleasant, and in a society where personal happiness is prized above all else, there is little tolerance for wallowing in despair. Especially now we've got drugs for it.

Antidepressants can help banish sad feelings - not just the life-sapping black dog of clinical depression, but the rough patches that most people go through sometimes, whether it's after losing a job, the break-up of a relationship or the death of a loved one. So it's no surprise that more and more people are taking them.

But is this really such a good idea? A growing number of cautionary voices from the world of mental health research are saying it isn't. They fear that the increasing tendency to treat normal sadness as if it were a disease is playing fast and loose with a crucial part of our biology. Sadness, they argue, serves an evolutionary purpose - and if we lose it, we lose out.

"When you find something this deeply in us biologically, you presume that it was selected because it had some advantage, otherwise we wouldn't have been burdened with it," says Jerome Wakefield, a clinical social worker at New York University and co-author of The Loss of Sadness: How psychiatry transformed normal sorrow into depressive disorder (with Allan Horwitz, Oxford University Press, 2007). "We're fooling around with part of our biological make-up."

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Researchers Discover A Protein That Amplifies Cell Death

Process of cell
© Albert Einstein College of MedicineExpression of a small fragment of p115 (green) leads to Cytochrome C (red) release in cells causing cell death.
Scientists at Albert Einstein College of Medicine of Yeshiva University have identified a small intracellular protein that helps cells commit suicide. The finding, reported as the "paper of the week" in the January 16th print issue of the Journal of Biological Chemistry, could lead to drugs for combating cancer and other diseases characterized by overproduction of cells. The research was led by the late Dennis Shields, Ph.D., a professor in Einstein's Department of Developmental and Molecular Biology for 30 years, who died unexpectedly in December.

In response to stress or as a natural part of aging, many cells undergo programmed suicide, also known as apoptosis. Cancer cells often become immortal and dangerous by developing the ability to suppress apoptosis.

A decade ago apoptosis was thought to be directed solely by the nucleus and mitochondria of cells. Dr. Shields' laboratory was the first to show that a cellular organelle known as the Golgi apparatus also plays a role in apoptosis.