Time to go back to
Eby and Eby. I have an inexplicable fondness for this paper. The information is decent if a touch unorganized, and the reliance on case studies reminds me (in a pleasing way) of old fashioned papers, such as
this one by John Cade about the use of lithium in mania.
When you start to untangle the effects of magnesium in the nervous system, you touch upon nearly every single biological mechanism for depression I've described so far in the archives of my blog. The epidemiological studies (1) and some controlled trials (
2)(
3) give us good reason to suspect that most of us are at least moderately deficient in magnesium. The animal models are promising (4). If you have healthy kidneys, magnesium supplementation is safe and generally well-tolerated (up to a point)(
5), and many of the formulations are quite inexpensive. Yet there is a woeful lack of well-designed, decent-sized randomized controlled trials of various psychiatric disorders and magnesium supplementation.
Let's look at the mechanisms first. Magnesium hangs out in the synapse between two neurons along with calcium and glutamate.
If you recall, calcium and glutamate are excitatory, and in excess,
toxic. They activate the NMDA receptor. Magnesium can sit on the NMDA receptor without activating it, like a guard at the gate. Therefore, if we are deficient in magnesium, there's no guard. Calcium and glutamate can activate the receptor like there is no tomorrow. In the long term, this damages the neurons, eventually leading to cell death. In the brain, that is not an easy situation to reverse or remedy.
And then there is the
stress-diathesis model of depression. The idea that chronic stress leads to hormonal imbalances of excess cortisol, which eventually
damages the hippocampus of the brain, leading to impaired negative feedback and thus ongoing stress and depression and neurotoxicity badness.
Murck shows that magnesium seems to act on many levels in the hormonal axis and regulation of the stress response.
Magnesium can suppress the ability of the hippocampus to stimulate the ultimate release of stress hormone, it can reduce the release of ACTH (the hormone that tells your adrenal glands to get in gear and pump out that cortisol and adrenaline), and it can reduce the responsiveness of the adrenal glands to ACTH. In addition, magnesium can act at the blood brain barrier to prevent the entrance of stress hormones into the brain.
Magnesium is the original chill pill.
Comment: The Professors statement above: "My understanding is that this farm in Germany was an organic one and there are more risks with organic food. For example organic chicken has more bugs than non-organic because they spend longer in the field and have wild bird droppings on them etc." is laughable, more risks with organic food?!
Based on the Professors statement, are we to conclude that 'Big Farma' or 'factory farmed' chicken is safer than free-range/organic chicken? Think again!
Two-Thirds of Chicken Tested Harbor Dangerous Bacteria
What Did The Chicken On Your Plate Eat?
As MRSA Gets Worse, the FDA Discovers Antibiotic Abuse on Factory Farms
Farmacology: Antibiotics resistance generated at factory farms
What the USDA Doesn't Want You to Know About Antibiotics and Factory Farms
Chicken, Antibiotic-resistant Bacteria, and Regulatory Independence
FDA Report: Alarming Amounts of "Superbugs" in Supermarkets
Speaking of bird droppings:
You Want Chicken Poop With That Steak? Why FDA Should Ban Feces From Feed