
© Mark Shriver, Penn StateThese are three-dimensional images of a face with location points indicated.
Genetic diseases and genetically mixed populations can help researchers understand human diversity and human origins according to a Penn State physical anthropologist.
"We wanted to get to a strategy to predict what a face will look like," said Mark D. Shriver, associate professor of biological anthropology. "We want to understand the path of evolution that leads to that part of the selection process."
To pinpoint genes that influence the shape of the human face and head, Shriver began with an online database of genes linked to disease -- Online Mendelian Inheritance of Man. If the symptoms of the disease involved the face or skull the gene implicated in the disease became a candidate for those facial traits.
This approach works because although Shriver looked at genes implicated in disease, those same genes in a healthy person may also influence the same physical trait -- length, width, shape, size -- but within the range normal for healthy individuals. Facial traits vary among humans, but do tend to group by population. For example, in general, West Africans have wider faces than Europeans and Europeans have longer faces than West Africans.