Kensington Palace confirmed the 36-year-old American actress is no longer a Facebook, Twitter and Instagram user.
The palace said: "Ms Markle is grateful to everyone who has followed her social media accounts over the years.
"However, as she has not used these accounts for some time, she has taken the decision to close them."
The move is in line with Royal tradition and comes after the Suits star closed her lifestyle blog The Tig in April last year.
However, Royal watchers need not despair, for like Kate Middleton, aspects of her life as a Royal will continue to feature on Kensington Palace's official account.
Comment: An account vetted by public relation professionals.
Sky's Royal Correspondent Rhiannon Mills said: "Meghan Markle was very vocal and active on her Twitter and Instagram accounts.
"It was the way she built 'her brand', sharing her life with her fans and more significantly her views on everything from political participation to racial equality.
"It is another sign of her rapid induction into 'Team Windsor' and a reminder that she will now have to be more careful about how she shares her views on the world. The Royals are after all expected to be politically neutral.
Comment: She certainly will:
"This isn't a sign that social media isn't important to the Royals. Over the past few years like any big organisation, they have increasingly focused on how they can use these new platforms to reach out to their loyal followers."
She added: "The fact that Harry and Meghan decided to release their third official engagement portrait on Instagram as a thank you for all the messages of congratulations is also a sign of how significant social media will continue to be in their married life."
Earlier this week, the palace issued photographs of Princess Charlotte's first day at nursery.
On Tuesday, Miss Markle and Prince Harry carried out their second official engagement and visited Brixton radio station Reprezent, which trains youngsters in media skills.
The couple will tie the knot on 19 May at St George's Chapel in Windsor, and the pair have previously said they want the public to feel a part of the celebrations.
Comment: And they will feel a part of it, by paying for the event with their tax money. It's a shame really because sometimes social media is the one place you can turn to when you want to read what babble these figureheads will come out with. Well, if we get desperate, there's always Prince Philip:
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