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The less you eat the longer you live, and the healthier you are, according to experts on aging and longevity, who've discovered fasting protects our genes and speeds up the regeneration of our cells.

"It's been known for a long time that one way to extend the lifespan of laboratory animals is simply to reduce their energy (calorie) intake," says
Mark Mattson, a neuroscientist at the National Institute on Aging and professor at Johns Hopkins University.

The lifespan of lab rats has been increased by up to 40 percent by feeding them less. In a Ted Talk titled Why Fasting Bolsters Brain Power, Mattson suggests humans could do the same by adopting a lifestyle of intermittent fasting:

"We started looking at the effects of energy restriction on the brain in the context of age-related neuro-degenerative disorders and found we could slow down ... Alzheimer's and Parkinson's," Mattson said.

Mattson said fasting improves brain function by challenging it. "Your brain responds to the challenge of not having food by activating pathways that help it cope with stress and resist disease."

Like vigorous exercise, intermittent fasting promotes neuron growth, strengthen synapses and increase production of new nerve cells. Fasting also increases the number of mitochondria in nerve cells, which improves cognition, memory and mood, and increases the ability of nerve cells to repair DNA, Mattson says.

When you fast, your metabolism shifts so that you start burning fats, he said. "Every time you eat a meal the energy is stored your liver in the form of glycogen [sugar]. That's always tapped into first. It takes 10-12 hours before you deplete the glycogen stores in your liver."

"When you eat three or four meals a day you never deplete the glycogen stores in your liver. You can't start burning fat until those stores are depleted. When you burn fats you produce ketone bodies, which are very good for your brain."

Fasting makes sense from an evolutionary perspective, Mattson notes. "Our hunter-gatherer ancestors would not have survived unless their brain was functioning at a high level when they were hungry. If you're hungry and haven't found food, you better figure out how to find food. You don't want your brain to shut down."

This may explain why nerve cell circuits become more active when we're hungry.

Director of USC Longevity Institute Valter Longo's research has led him to similar conclusions.

In his own Ted Talk called Fasting: Awakening Rejuvenation From Within, he explains how fasting triggers the body to regenerate itself.

It started with the discovery that fasting protects mice against the damaging effects of chemotherapy. After six sessions of chemo, only the mice who fasted were able to restore their white blood cell count back to normal, Longo said.

Longo and his fellow researchers wondered how this was possible.

"We started thinking about regeneration. Is it possible that fasting is telling the body to generate new cells and regenerate the immune system?" Longo said.

So they took middle-aged mice, put them on a fast, and found it reversed the effect of aging on the white blood cell count.

"Something in fasting creates gene protection," he said.

It works by activating our stem cells and temporarily reducing the number of immune cells during the fast. Then when we start eating again, the activated stem cells go to work creating new immune cells.

Fasting the Cure
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"After just a couple days your body completely reprograms itself," Longo said.

He and his team also conducted studies showing fasting drastically reduces risk factors associated with diabetes, cancer and heart disease, while increasing the number of circulating stem cells.

So why is the standard Western diet three meals a day plus snacks?

Not surprisingly, Mattson said it boils down to money. The food industry doesn't make money when people skip breakfast. Neither does pharmaceutical industry.

Fasting Methods

Mattson says there are two basic ways to experience the health benefits of calorie restriction - eat less at each meal, or reduce the frequency of the meals, aka intermittent fasting.

Popular intermittent fasting methods:

1. Long water-only fasts - two days a month or two weeks a year

2. Alternate day fasting - less than 600 calories, or no food, every other day

3. 5:2 diet - eating normally 5 days a week, less than 600 calories the other two days

4. Daily time-restricted fasting - food is only consumed during a 4-8 hour period each day

Your brain, which is typically run by sugar, switches to fat for fuel during fasting. "This is why people usually get a headache after they fast for the first time," Longo warns.

But not to worry, he says, most of us can go 60 days without food. Some people can actually go for 6 months. "This used to be common practice in many religions, but has been forgotten."

Quotes by famous fasters:

"I fast for greater physical and mental efficiency." Plato

"Fasting is the greatest remedy - the physician within." Philippus Paracelsus

"A little starvation can really do more for the average sick man than the best medicines and the best doctors." Mark Twain

"Humans live on one-quarter of what they eat; on the other three quarters lives their doctor." Egyptian pyramid inscription, 3800 BC