A scientific paper confirming the relationship between autonomic nervous system dysfunction and Gulf War Illness was published online November 26, 2012 in the Archives of Neurology, according to Targeted Medical Pharma, Inc. (OTCQB: TRGM) (OTCBB: TRGM), a specialty pharmaceutical company that develops and distributes prescription medical foods to physicians and pharmacies.


Comment: Here we go again, the always-present Big Pharma-sponsored medical research...


The paper, "Cholinergic Autonomic Dysfunction in Veterans with Gulf War Illness," revealed a blunting or loss of normal nighttime parasympathetic activity in veterans suffering from Gulf War Illness was strongly associated with upper gastrointestinal dysmotility and sleep dysfunction. The abstract of the study can be viewed by visiting: [link]

"The results of this study confirm our company's approach to the management of Gulf War Illness and other diseases involving disordered autonomic function," said William Shell, M.D., CEO and chief scientific officer of Targeted Medical Pharma, Inc., co-author of the scientific paper who provided data, analysis, and manuscript revisions, along with the late Elizabeth Charuvastra, RN, co-founder of Targeted Medical Pharma. "Our company is poised to educate military and civilian healthcare providers how to utilize the prescription-only medical foods Sentra AM ® and Sentra PM ® as part of a regimen to manage autonomic dysfunction associated with Gulf War Illness and other chronic diseases."


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The scientific paper was primarily designed and implemented by Dr. Robert W. Haley, chief of epidemiology at the University of Texas Southwestern Medical Center, and Dr. Steven Vernino, chief of the neuromuscular division at the University of Texas Southwestern Medical Center.

"This is the first study to establish a medical basis for symptoms of Gulf War Illness in a large, representative sample of veterans using validated medical tests," said Dr. Haley, principal author of the paper. "It now gives physicians a medical condition they can test for and treat."

Funded by the U.S. Department of Veterans Affairs, U.S. Army Medical Research and Material Command, and the National Institute of Health, the study looked at 97 Gulf War-era veterans who met the standardized case definition of Gulf War Illness. The authors of prior studies raised the hypothesis that symptoms in veterans of the 1991 Gulf War, such as chronic diarrhea, dizziness, fatigue, and sexual dysfunction, are due to cholinergic autonomic dysfunction.