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That fills the agenda, doesnt it?Yeah, but maybe they are loosing too many orks in the process.
Very few synthetic drugs generate an immediate and powerful impact in the biomedical field shortly after their inception. This has been the case particularly within the areas of pre-surgical, surgical, and post-surgical anesthesiology where the need for fast acting, effective pain relievers is a key element in the overall patient care practice. Morphine (1) and Tramadol (2) are two opioid-based compounds that are widely recognized for being the gold standard prescriptions for patients with moderate to severe pain after surgery or with certain disease states ( e.g. cancer). Due to their potency, these therapeutics, however, are also well known for their ability to foster chemical dependencies in patients and other users.
Though it is often difficult to surpass the established therapeutic records and efficiency profiles by the aforementioned drugs, occasionally new drug candidates are identified that accomplish this seemingly difficult feat. Such is the case for a class of synthetic alkaloids whose birth and swift entrance in the medical field of anaesthesiology originated with the synthesis of fentanyl ( 4) by Paul Janssen in 1960 . Since its synthesis, inspired partly by the necessity to improve the potency and bioavailability of the structurally related opiate Demerol ( 3 ) , fentanyl analogs with superior pharmacokinetic properties, onset time, and effective dosage have been successfully produced. Currently, a significant array of fentanyl analogs exists spanning a large range of physicochemical properties , which strictly determine their ultimate application. Some of these compounds, along with their potency relative to morphine, are given in Fig. 2.
Fentanyl (prescribed more commonly by its trade name Sublimaze) is approximately 50–100 times more potent than morphine, a quality that has righteously cemented this drug and its congeners in the medical field as the primary choice for a fast acting anesthetic during perioperative procedures. Their modus operandi is believed to involve the binding to the transmembrane µ-opioid receptors on cell surfaces resulting in a cascade of intracellular signals that eventually results in their biological effect. Even though to date a detailed description of this receptor binding event remains undiscovered , a suitable model can be proposed based on the known binding of similar opioids to various nociceptive/opioid receptors for which few crystallographic structures have been solved.
fentanyl analogs exists spanning a large range of physicochemical propertiesI wonder if that means fentanyl affects the DNA.
Abstract. Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenylethylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyltion-cyclization followed by Swern oxidation.And regarding phenylethylamine from Sanesco Health [Link]
Share. Phenylethylamine (PEA), also known as beta-phenylethylamine or 2-phenylethylamine, is a central nervous system stimulant. Normal amounts of PEA produced in the body support healthy energy levels as well as attention and focus, well-being, happiness, and cognitive function.and of course Wikipedia [Link]
an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans.
Discovery and Biosynthesis of Antimicrobial Phenethylamine Alkaloids from the Marine Flavobacterium Tenacibaculum discolor sv11and Googling "Tenacibaculum discolor sv11" discovered:
Tenacibaculum is a Gram-negative and motile bacterial genus from the family of Flavobacteriaceae. Many opportunistic pathogens for fish species are included in the genus Tenacibaculumand going to ScienceDirect [Link] it explains :
The use of the phenethylamine derivative and amphetamine-like compound methylphenidate ( Ritalin ) has increased over the last 20 years primarily for the treatment of attention-deficit hyperactivity disorder (ADHD) in children and increasingly in adults.but essentially, Wikipedia is my God and tells me that simply:
Phenethylamines are stimulant, entactogenic, and hallucinogenic substances that share similar chemical structures with amphetamine , catecholamines, synthetic cathinones, and other substances
Fentanyl is a potent synthetic piperidine opioid primarily used as an analgesic. It is 50 times more potent than heroin and 100 times more potent than morphineand under History:
Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist Auguste Cahours, who named it.and it has been around for a while... I thought the Chinese made it? More lies I fell for?
Fentanyl was first synthesized by Paul Janssen in 1959 and was approved for medical use in the United States in 1968. In 2015, 1,600 kilograms (3,500 pounds) were used in healthcare globally. As of 2017, fentanyl was the most widely used synthetic opioid in medicine; in 2019, it was the 278th most commonly prescribed medication in the United States, with more than a million prescriptions. It is on the World Health Organization's List of Essential Medicines. Fentanyl continues to fuel an epidemic of synthetic opioid drug overdose deaths in the United States.
"Anderson’s work on pyridine and picoline involved studies on the distillation of bone oil and other animal matter.so it would be dead rotting fish... "Tenacibaculosis occurs due to the marine bacterial pathogen Tenacibaculum maritimum. This ulcerative disease causes high mortalities for various marine fish species worldwide." [Link] Bing says it:
manifests as lesions on the body , necrosis , frayed fins , tail rot , eroded mouth , and sometimes necrosis on the gills and eyes .and:
Cultivation and Biochemical Characterization : Diagnosis involves cultivating and characterizing the bacteria through biochemical tests.So when you mention "off-shoot of the fishing industry" maybe that just means they now have a market for 150 years for dead, rotten fish which normally would've been a cost; I suppose it is interesting that something so 'crucial' (pain relief) comes from a most horrific, disgusting deadly bacterial infection...
Real-Time RT-PCR : The bacterium Tenacibaculum maritimum can be detected internally using real-time RT-PCR.
Targeting Teeth : Tenacibaculum bacteria specifically target teeth , which are rich in the calcium needed for their growth.
Systematic Presence : T. maritimum can also be isolated from the kidney , suggesting it is a systematic infection.
It does get fishier and stinkier as every covering gets pealed off.
I've even heard that the human sacrifice cults of the Aztecs did such horrific procedures, just so their power-addicted priests could get their fix of 'prohibited knowledge'... How many more original sins are being unleashed on humankind for want of knowledge? I always thought 'sin' was based in ignorance... maybe there is a sin based in knowing?Well, there is the 'downward' way or the 'upward' way, you could say... and both involve gaining knowledge from ignorance; but down only wants power, and up only wants sharing.... the knowledge seats itself as it can.
The illegals are the exception they need them to vote for the Democrats so they get out of jail free card.Interesting perspective... Play the no-more-liberal card right before elections... I doubt there are enough damaged-shattered-broken folk able to vote... But with the fear that their substance could dry up, it may inspire them to tick a box. Also, repealing their disaster policies before elections almost gives them the illusion that they are slightly resolving problems (albeit enormous problems they made).
Comment: Hot Air adds: