A research team, led by Professor Hideshi Ihara from the Osaka Metropolitan University Graduate School of Science, was the first to discover 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) -- which have one more oxygen atom than normal IDPs -- and found that they are the most common variety of IDPs derivatives in the body. The researchers also found that they have remarkably high antioxidant activity.
In their study, the researchers established a method for selective and highly sensitive detection of five types of 2-oxo-IDPs using mass spectrometry, which enables quantitative detection of trace 2-oxo-IDPs in living organisms. Using this method, they revealed for the first time that beef, pork, chicken, and other meats contain antioxidants, not only IDPs but a variety of different 2-oxo-IDPs. Their findings were published in Antioxidants.
"We hope that this research method, which enables advanced analysis of 2-oxo-IDPs, will be applied not only to basic biology but also to medicine, agriculture, and pharmacy, where it will help improve peoples' health and prevent diseases," concluded Professor Ihara.
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Materials provided by Osaka Metropolitan University. Note: Content may be edited for style and length.
Journal Reference:
- Somei Komae, Shingo Kasamatsu, Koji Uchida, Hideshi Ihara. Quantitative Determination of 2-Oxo-Imidazole-Containing Dipeptides by High-Performance Liquid Chromatography/Tandem Mass Spectrometry. Antioxidants, 2022; 11 (12): 2401 DOI: 10.3390/antiox11122401
Comment: This flies in the face of established nutritional dogma which insists that plant-foods are the only means why which humans can obtain anti-oxidants, and therefore should be consuming large amounts of fruits and vegetables to support their health.
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