Researchers have found that many people with autism share common genetic variations, a discovery that may improve diagnosis and offers the promise of developing treatments for the frustratingly mysterious disorder.

Their findings, published in the journal Nature, compared the genomes of thousands of autistic people to those of thousands of people without the disorder - a massive task that new technology has only recently made possible. The genome is the complex system of DNA coding that builds and runs the human body.

The review showed that most autistic people have a genetic variation in a portion of their DNA that affects the way brain cells connect with one another. Scientists also reported a link between autism and small "mistakes" in another DNA segment involved with cell communication.

Both reports add weight to the idea that autism is related to problems with the way brain cells connect.

"It is very exciting," said study leader Hakon Hakonarson, director of the Center for Applied Genomics at Children's Hospital of Philadelphia. "It opens up the opportunity someday for new interventions to fix the bad consequences this variant has on brain function and development."

A disorder marked by impaired language and the ability to interact, autism affects one in 150 children in the U.S., according to the federal Centers for Disease Control and Prevention.

Up to now, the medical community could say very little about what causes autism or how to treat it. The lack of scientific knowledge about autism has led to a proliferation of pseudoscientific explanations for the disorder, as well as unproven treatments that are often costly and sometimes unsafe.

Though this is not the first time geneticists have found a link between autism and DNA, past discoveries have involved extremely rare instances where a tiny bit of DNA was missing or there were too many copies of another bit. Those differences were helpful in understanding how trouble in those regions of the genome can lead to autistic symptoms, but they accounted for only a tiny fraction of autism cases.

By contrast, the new research is "a big step," said Tom Lehner, chief of the Genomics Research Branch at the National Institute of Mental Health. "It opens up biology. With biology, you can find drug targets. Understanding the molecular networks, this is the big importance of these findings."

The first of two Nature studies published online recently found that 65 percent of autistic participants shared a variation between cadherin 10 and cadherin 9, a region of the genome that controls cell-adhesion molecules in the brain. Those molecules help brain cells connect, and autism researchers have long suspected that trouble there may be linked to the disorder.

"If we could remove this variant from the population, just take it away "... as much as 25 percent of autism would disappear, which is highly significant," Hakonarson said.

The second study suggested a link between autism and an excess of genetic material associated with ubiquitin, a protein involved with cell-adhesion molecules and connections between brain cells.

News of the findings has excited other autism researchers. Laura Herzing, who researches autism and genetics at Children's Memorial Research Center at Northwestern University, said the ubiquitin findings dovetailed with her own research.

"It will directly affect what I am doing," she said. "Identification of pathways in this way lets us know that we should also be looking closely at other genes and proteins in those pathways as well."

Researchers warned against using the findings to, say, check your child's genome for signs of autism. The variations show increased risk but are not conclusive markers of the disorder.

The reports also do not explain the rising numbers of diagnosed cases of autism. That increase may be occurring because of heightened awareness of the disorder, because the definition of autism has expanded or because of some environmental factor. It may be some combination these factors or something else entirely.

Still, autism activists are celebrating some good news for a disorder that has frustrated so many for so long.

"Speaking as a parent, studies like this are a huge source of hope," said Alison Singer, president of the nonprofit Autism Science Foundation and mother of a child with autism. "They can lead to the development of safe, effective and novel treatments that enhance quality of life for children and adults with autism spectrum disorders."