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© The Associated Press
Two members of President Barack Obama's cabinet will be in St. Louis this Thursday morning to lead the nation in a first of its kind multistate public earthquake drill.

Secretary of Education Arne Duncan and Secretary of Homeland Security Janet Napolitano will join Missouri Governor Jay Nixon at Carnahan High School of the Future for what has been called "the Great Central U.S. ShakeOut."

More than 2.7 million Americans across 2,016 schools and 82 colleges and universities will participate in the drill.

The drill will be conducted along the earthquake-prone region known as the New Madrid Seismic Zone. Scientists predict a major earthquake could hit this region in the next 50 years.