© H. Morrison, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of EdinburghA mouse embryo: red indicates where a gene regulatory sequence is active.
Even the prettiest faces are built using junk. In mice, the shapes of the face and skull are finely tuned by
junk DNA, so called because it was initially thought to lack function since it doesn't encode proteins. The same junk DNA sequences are found in humans, so they are probably also shaping our faces.
This finding could help us make sense of some congenital conditions, such as cleft palates, that can develop even when the genes that shape the face appear to be working normally.
There is a huge degree of variation in human faces but,
as family resemblances show, the overall shape is heavily constrained by genetics. However, so far, geneticists have identified only a small number of genes that influence the shape. These explain just a tiny fraction of the variation seen in human faces.
According to
Axel Visel of the Lawrence Berkeley National Laboratory in California and his colleagues, more variation is controlled by distant-acting enhancers. These are short sequences of DNA, in non-coding regions of the genome, that can influence the activity of the facial genes, even if they are a long way along the DNA strand.
"Enhancers are part of the 98 per cent of the human genome that is non-coding DNA - long thought of as 'junk DNA'," says Visel. "It's increasingly clear that important functions are embedded in this 'junk'."
Comment: For more information on Junk DNA and how to protect it, see On viral 'junk' DNA, a DNA-enhancing Ketogenic diet, and cometary kicks