© Penny Lee / UCI School of MedicineThe future implications of our findings are vast,” says Paolo Sassone-Corsi, senior author of one of the two studies on circadian clocks published today in the journal Cell. He directs UCI’s Center for Epigenetics and Metabolism and is a Donald Bren Professor of Biological Chemistry.
Can your liver sense when you're staring at a television screen or cellphone late at night?
Apparently so, and when such activity is detected, the organ can throw your circadian rhythms out of whack, leaving you more susceptible to health problems.That's one of the takeaways from two new studies by University of California, Irvine scientists working in collaboration with the Institute for Research in Biomedicine in Barcelona, Spain.
The studies,
published today in the journal
Cell, used specially bred mice to analyze the network of internal clocks that regulate metabolism. Although researchers had suspected that the body's various circadian clocks could operate independently from the central clock in the hypothalamus of the brain, there was previously no way to test the theory, said
Paolo Sassone-Corsi, director of UCI's Center for Epigenetics and Metabolism and senior author of one of the studies.
To overcome that obstacle, scientists figured out how to disable the entire circadian system of the mice, then jump-start individual clocks. For the experiments reported in the
Cell papers, they activated clocks inside the liver or skin.
"The results were quite surprising," said Sassone-Corsi, Donald Bren Professor of Biological Chemistry.
"No one realized that the liver or skin could be so directly affected by light."For example, despite the shutdown of all other body clocks, including the central brain clock, the liver knew what time it was, responded to light changes as day shifted to night and maintained critical functions, such as preparing to digest food at mealtime and converting glucose to energy.
Somehow, the liver's circadian clock was able to detect light, presumably via signals from other organs. Only when the mice were subjected to constant darkness did the liver's clock stop functioning.
Comment: Could it be that because listening to particular kinds of music already engages creativity, memory recall, visualization and so on, attempting to do more than just listening to the music is akin to multi-tasking?