The Groveland police department issued a warning on Tuesday to residents of the town located about 35 miles north of Boston, saying the animal is on the loose and likely to have rabies.
"We are asking all residents to be watchful and when outside use extra care for your safety and the safety of your children and pets," said deputy chief Jeffrey Gillen.
Coyote attacks on humans are generally rare, but incidents have increased in some parts of the country in recent years alongside suburban encroachment on wild areas.
Police said the coyote bit one man as he was entering his home with his 4-year-old daughter, leading him to seek emergency treatment at a local hospital.
The coyote later attacked another homeowner in his front yard. That resident "had to kick the animal several times before it left the area," the police said in a press release.
Comment: Animals have been attacking humans with increasing regularity lately. Even beloved pets are turning on their owners. Perhaps the animal kingdom is reflecting the increasingly bizarre and deteriorating behavior that humans have been exhibiting recently.
Pack of coyotes chases man and dog through Burbank neighborhood, California
Coyote attacks second young girl in Rye, New York
Spike in coyote attacks on animal pets in Claremont, California
Woman and dogs attacked by coyote in front of her Kilworthy home, Ontario