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The plane went off the runway at Yeager Airport on Friday morning.
Yeager Airport spokesman Mike Plante said the cargo plane had departed from Louisville, Kentucky and was trying to land at 5:33 am when it went off the runway.
The crash occurred when the left wing of the cargo propeller struck the runway, according to federal and local officials.
"It hit the runway...hard (and) went off into a wooded area," said Plante according to West V Virginia Metro News.
A wing is detached and near the runway. The aircraft is 45 meters (150 feet) over the hill.
New outlets report that emergency crews are at the scene. Emergency workers had to use chain saws to cut their way to the site.
"It's difficult terrain to negotiate," Plante said.
"I, myself am a commercial pilot," Plante said, according to WHAS. "Whenever you have something like this happen, you're reminded of that aviation, as wonderful as it is, can be incredibly unforgiving."
The National Transportation Safety Board is going to investigate. Airport operations have been halted. The names of those killed have not been released.
The National Weather Service reported clouds were as low as 30 meters (100 feet) in the area at the time of the crash, and it was raining earlier in the morning.
"reverse" on the engines. I need a picture to show you how this works. It's that intense deceleration that makes you usually feel uncomfortable. When I say reverse on the jet engines, don't imagine that suddenly the blades inside the jet engines start to turn the other way. That would literally reap those engines apart. Again I need a short video to make you understand the process plus you need basic knowledge of physics.
Propeller engines are outdated , yet still used as they are cheaper. In this particular case , it looks like the crew lost more power than they should on the left engine, forcing the entire plane to bank left, the wing striking the ground and from then on it was all over.