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Signs of the Times for Fri, 19 May 2006

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18/05/2006
As ClinicalTrials.gov reveals, in 2005, Massachusetts General Hospital conducted an 8-week trial study that recruited children as young as four years old to be drugged and monitored, including having their blood drawn, to see if their tiny four-year-old bodies would tolerate a powerful psychotropic drug (Seroquel).

Here's more from ClinicalTrials.gov:

This is an 8-week open-label study aimed at assessing the effectiveness and tolerability of Quetiapine, in the treatment of preschool children aged 4 to 6 years with bipolar and bipolar spectrum disorder. This is an exploratory, pilot study, seeking to determine whether Quetiapine is efficacious and well tolerated in the treatment of preschoolers with pediatric bipolar and bipolar spectrum disorder in this age group.

Ages Eligible for Study:4 Years - 6 Years, Genders Eligible for Study: Both

Subject must be able to participate in mandatory blood draws.

Massachusetts General Hospital, Cambridge, Massachusetts, 02138, United States; Recruiting

Joseph Biederman, MD, Principal Investigator...

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By LINDA A. JOHNSON
AP Business Writer
Fri May 19, 2006
TRENTON, N.J. - Unpublished data from the Merck & Co. study that led the drugmaker to halt sales of Vioxx appear to show the blockbuster painkiller raised the risk of heart attack and stroke within just a few months - not after at least 18 months' use, as Merck has consistently argued.

The company disputed that Thursday, saying it is "not scientifically appropriate" to draw conclusions based on a key graph in a 108-page report on the data.

The news, first reported by National Public Radio, comes after prominent doctors said Merck misrepresented other data from the same study late last Thursday.

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AFP
Friday May 19, 2006
Indonesia's bird flu toll has risen to 32 as the World Health Organisation (WHO) confirmed two more deaths from the virus in the world's fourth most populous nation.

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