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It hit about 9:00pm (AEST), with the epicentre near Moe in west Gippsland, about 120 kilometres south-east of Melbourne.
Geoscience Australia says the 5.3 quake had a depth of about 10km and rumbled through Melbourne and communities including Bendigo, Ballarat, Geelong and Shepparton.
People have reported hearing a roaring noise, with reports of cracks occurring in the walls and floors of homes.
Victoria Police say they have received a number of calls in relation to the tremor.
They say they have not received any reports of major damage.
The Victorian State Emergency Service (SES) says they have received 40 requests for assistance in the broader Gippsland area and parts of Melbourne, but no reports of significant damage.
The SES's Lachlan Quick says most of the request of assistance have come from areas near the epicentre.